Key result
Cardiac aging links to fibroblast dysregulation driven by the obligate role of DDR2 in fibrosis.
Why the study?
Although the phenotypes of cardiac aging are well characterised, the underlying molecular mechanisms remain far less explored.
Design
Review
Authors
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DDR2 dysregulation contributes to age-related cardiac fibrosis; leaves open whether targeting it improves outcomes in older adults.
Understanding the molecular basis of cardiovascular aging, particularly the role of DDR2 in cardiac fibroblasts, may help develop strategies to mitigate cardiovascular diseases in the elderly.
Vijayakumar et al. (2024) conducted a review in Cardiovascular aging. Cardiac aging is linked to dysregulation of signaling pathways in cardiac fibroblasts, with Discoidin domain receptor 2 (DDR2) playing an obligate role in fibroblast function and cardiovascular fibrosis.
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