Key result
Noninvasive imaging of LV rotational mechanics serves as a sensitive marker for cardiac dysfunction.
Assessment of left ventricular rotational mechanics via noninvasive imaging may provide important insights into the pathophysiology of heart failure and serve as a sensitive marker of cardiac dysfunction.
Highlights potential of LV rotational mechanics assessment in HF; leaves open prospective validation before clinical use.
Left ventricular (LV) torsion (twisting) and untwisting results in equalization of wall stress and augmentation of pressure generated for a given shortening of sarcomere during the systolic contraction and aids early diastolic relaxation. This is attributed to the dynamic interaction of epicardial and endocardial helical myocardial fibers. Recent advances in noninvasive imaging techniques have enabled us to quantify torsion accurately and reliably in health and disease. LV torsional mechanics are altered in range of clinical conditions from those that cause minimal cardiac architectural changes as seen in hypertension, diabetes mellitus or older age to advanced cardiac remodeling as seen dilated or hypertrophic cardiomyopathy. Therefore, assessment of LV rotational mechanics may be a potentially sensitive marker of cardiac dysfunction and may provide important insights into the pathophysiology of heart failure.
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Pokharel et al. (2014) conducted a review in Cardiac dysfunction. Noninvasive measurement of myocardial twist and torsion was evaluated. Assessment of left ventricular rotational mechanics via noninvasive imaging may serve as a sensitive marker of cardiac dysfunction and provide insights into heart failure pathophysiology.
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