Key result
Highest quartile remnant cholesterol linked to ~49% greater odds of depression versus the lowest.
Why the study?
Remnant cholesterol is linked to various diseases, but its relationship with depression had not been studied.
Is higher remnant cholesterol concentration associated with increased odds of depression in US adults?
Population
8,263 adults from NHANES 2005-2016
Comparison
Remnant cholesterol concentration levels
Design
Cross-sectional analysis
Authors
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Associated with higher depression odds in US adults; leaves open causality and clinical relevance pending prospective studies.
Cross-Sectional (n=8,263)
Is higher remnant cholesterol concentration associated with increased odds of depression in US adults?
Effect estimate: OR 1.49 (95% CI 1.02-2.17)
p-value: p=0.04
Higher remnant cholesterol concentrations are significantly associated with an increased likelihood of depression among US adults.
Wang et al. (2023) conducted a cross-sectional in Depression (n=8,263). Highest quartile of remnant cholesterol vs. Lowest quartile of remnant cholesterol was evaluated on Depression (PHQ-9 score ≥ 10) (OR 1.49, 95% CI 1.02-2.17, p=0.04). Remnant cholesterol concentration in the highest quartile was significantly associated with higher odds of depression compared to the lowest quartile (OR 1.49).
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