Key result
Aspirin for primary CV prevention requires individualized approaches due to narrow safety margins from bleeding.
Why the study?
In primary cardiovascular prevention, aspirin carries an excess bleeding risk that narrows its safety margin, leading to variable scientific society recommendations and a need to explore new perspectives for an individualized approach.
Does aspirin prevent cardiovascular events in primary prevention?
Design
Review
Authors
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Requires cautious aspirin use in primary prevention; leaves open optimal subgroup selection for future trials.
Does aspirin prevent cardiovascular events in primary prevention?
The use of aspirin in primary prevention requires a comprehensive individualized approach due to the competing risks of atherothrombosis and bleeding, and the dynamic nature of cardiovascular risk.
Bona et al. (2024) conducted a review in Primary prevention of cardiovascular disease. Aspirin was evaluated. Aspirin for primary cardiovascular prevention presents a narrow safety margin due to bleeding risks, highlighting the need for individualized approaches in specific subgroups like diabetes or obesity.
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