What question did this study set out to answer?

To examine the association between the diagnosis-to-first-treatment interval and five-year all-cause mortality risk in patients with newly diagnosed early-stage breast cancer.

May 22, 2025BMC Women s HealthOpen Access

Impact of diagnosis-to-treatment interval on mortality in patients with early-stage breast cancer: a retrospective nationwide Korean cohort

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Authors

SJSung Hoon JeongInje University SCSeong Min ChunSoonchunhyang University Hospital Seoul HLHyunji LeeEwha Womans University

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Implication

Retrospective cohort study finds that treatment delays exceeding 60 days double five-year mortality in early-stage breast cancer, highlighting the critical need for prompt clinical interventions.

Key Points

To examine the association between the diagnosis-to-first-treatment interval and five-year all-cause mortality risk in patients with newly diagnosed early-stage breast cancer.
Conducted a nationwide retrospective cohort study using data from the Korean National Health Insurance and Korea National Cancer Incidence databases (2006–2017).
Performed 1:5 propensity score matching to balance 725 patients with a diagnosis-to-first-treatment interval (DFTI) ≥ 60 days against 3,625 patients with a DFTI < 60 days.
Estimated 5-year all-cause mortality using Cox proportional hazards regression models, with secondary sensitivity analyses evaluating a 45-day threshold.
A DFTI ≥ 60 days was associated with significantly higher 5-year all-cause mortality compared to a DFTI < 60 days (hazard ratio [HR] 2.09, 95% CI 1.43–3.06).
A secondary threshold analysis confirmed that a DFTI ≥ 45 days also correlated with increased mortality compared to DFTI < 45 days (HR 1.49, 95% CI 1.14–1.96).
The elevated mortality risk associated with treatment delay was amplified among individuals residing in rural regions, those with lower household income, and those with a high Charlson comorbidity index.

Cite This Study

Jeong et al. (2025) studied this question.

synapsesocial.com/papers/6a0ec73f37aeb0126447ab34 https://doi.org/10.1186/s12905-025-03780-6

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Implication

Retrospective cohort study finds that treatment delays exceeding 60 days double five-year mortality in early-stage breast cancer, highlighting the critical need for prompt clinical interventions.

Impact of diagnosis-to-treatment interval on mortality in patients with early-stage breast cancer: a retrospective nationwide Korean cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

Impact of diagnosis-to-treatment interval on mortality in patients with early-stage breast cancer: a retrospective nationwide Korean cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

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