What question did this study set out to answer?

To evaluate the diagnostic accuracy of the NINCDS/ADRDA and DSM-III-R clinical criteria in relation to three pathological diagnostic standards for Alzheimer's disease.

January 1, 1998Dementia and Geriatric Cognitive Disorders

Accuracy of Clinical Operational Diagnostic Criteria for Alzheimer’s Disease in Relation to Different Pathological Diagnostic Protocols

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Authors

ZNZsuzsanna NagyUniversity of Birmingham MEM M EsiriUniversity of Oxford NHNicholas HindleyThe University of Sydney

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Implication

Diagnostic accuracy study reveals poor sensitivity and negative predictive value of clinical Alzheimer's criteria against neuropathology, highlighting substantial limitations in routine clinical...

Key Points

To evaluate the diagnostic accuracy of the NINCDS/ADRDA and DSM-III-R clinical criteria in relation to three pathological diagnostic standards for Alzheimer's disease.
Assessed two clinical diagnostic frameworks (NINCDS/ADRDA and DSM-III-R) against three postmortem pathological protocols: Khachaturian criteria, Tierney A3 criteria, and the CERAD protocol.
Determined clinical diagnostic validity by calculating sensitivity, specificity, positive predictive value, and negative predictive value across each pathological reference standard.
Individual clinical criteria showed poor sensitivity (34–58%) across all pathological protocols.
Combining NINCDS/ADRDA 'possible' and 'probable' dementia categories achieved high sensitivity (91–98%) but resulted in poor specificity (40–61%).
Positive predictive values for NINCDS 'probable' status and DSM-III-R criteria were high (89–100%), whereas negative predictive values were low (33–63%).

Cite This Study

Nagy et al. (1998) studied this question.

synapsesocial.com/papers/6a0ec908218372ada647b9dc https://doi.org/10.1159/000017050

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Implication

Diagnostic accuracy study reveals poor sensitivity and negative predictive value of clinical Alzheimer's criteria against neuropathology, highlighting substantial limitations in routine clinical...

Accuracy of Clinical Operational Diagnostic Criteria for Alzheimer’s Disease in Relation to Different Pathological Diagnostic Protocols

Discussion

Member takes

Implication

Key Points

Cite This Study

Accuracy of Clinical Operational Diagnostic Criteria for Alzheimer’s Disease in Relation to Different Pathological Diagnostic Protocols

Discussion

Member takes

Implication

Key Points

Cite This Study

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