Key result
Pacing ventricular areas with longest baseline repolarization improves pump function versus shorter repolarization in animals.
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Does not support clinical adoption; hypothesis-generating for repolarization-guided pacing in humans.
Introduction The investigation of the pump function of the hearts in different classes of vertebrates having different types of myocardial activation is of considerable significance for the comparative electrocardiology. In most investigations [1-6] pump function is studied only in the left ventricle (LV), whereas little is known about RV in the full-blooded vertebrates [7].
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Киблер et al. (2018) studied Healthy animals undergoing ectopic excitation of ventricles (n=50). Ventricular pacing at areas of different repolarization durations (apex vs. base) vs. Supraventricular rhythm and pacing at alternate ventricular sites was evaluated on Indices of ventricular pump function (maximal systolic pressure, dP/dtmax, dP/dtmin) (p=<0.05). Pacing the ventricular area with the longest baseline repolarization duration resulted in better pump function parameters compared to pacing areas with shorter repolarization in dogs and amphibians.
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