Key result
In a theoretical canine electromechanical model, left ventricle pacing demonstrated the best performance in ventricular pumping efficacy compared to apex and right ventricular free wall pacing.
Why the study?
Does pacemaker location affect cardiac pumping efficacy in a computational model of canine ventricles?
Does pacemaker location affect cardiac pumping efficacy in a computational model of canine ventricles?
In a computational model of canine ventricles, left ventricular pacing demonstrated superior pumping efficacy compared to apical or right ventricular pacing.
Answers are grounded in this paper and cite their sources.
Model results should not alter pacing practices; leaves open prospective human validation of LV lead sites.
The purpose of the study is to examine the effects of pacemaker location on cardiac pumping efficacy theoretically. We used a three-dimensional finite element cardiac electromechanical model of canine ventricles with models of the circulatory system. Electrical activation time for normal sinus rhythm and artificial pacing in apex, left ventricular free wall, and right ventricular free wall were obtained from electrophysiological model. We applied the electrical activation time maps to the mechanical contraction model and obtained cardiac mechanical responses such as myocardial contractile ATP consumption, stroke work, stroke volume, ejection fraction, and etc. Among three artificial pacing methods, left ventricle pacing showed best performance in ventricular pumping efficacy.
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Kim et al. (2015) studied Cardiac pacing. Left ventricle pacing vs. Apex and right ventricular free wall pacing was evaluated on Ventricular pumping efficacy (myocardial contractile ATP consumption, stroke work, stroke volume, ejection fraction). In a theoretical canine electromechanical model, left ventricle pacing demonstrated the best performance in ventricular pumping efficacy compared to apex and right ventricular free wall pacing.
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