Key result
A Purkinje geometry with a high density of Purkinje muscle junctions and transmural/apex-to-base action potential gradients is necessary to produce physiologically accurate ECGs and activation plots.
Population
Ex vivo, healthy, female New Zealand White rabbit heart model
Comparison
Computational model of cardiac ventricular… vs Models with low Purkinje-muscle junction…
Design
Preclinical
Authors
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computational models of ventricular arrhythmias should incorporate these specific gradients; leaves open whether these.
Accurate computational modeling of ventricular electrophysiology requires high-density Purkinje-muscle junctions and spatial action potential gradients to reproduce physiological ECGs and activation sequences.
Krishnamoorthi et al. (2014) studied Healthy (Cardiac Ventricular Electrophysiology Modeling) (n=1). High density Purkinje muscle junction model with action potential gradients vs. Low density PMJ model or no Purkinje structure was evaluated on Physiologically accurate ECG and ventricular activation sequence. A Purkinje geometry with a high density of Purkinje muscle junctions and transmural/apex-to-base action potential gradients is necessary to produce physiologically accurate ECGs and activation plots.
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