Key result
Ventricular fibrillation signatures in computational swine heart models were mainly controlled by anatomy and structural parameters rather than by regional restitution properties.
Why the study?
The complexity and multiscale nature of the heart limit predictability, raising the question of the optimal modeling choice for large-scale whole-heart numerical investigations.
Population
Three-dimensional healthy and infarcted swine heart geometries
Comparison
Simplified phenomenological vs detailed biophysical electrophysiological modeling approaches
Design
Numerical simulation study
Authors
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May guide modeling choices in computational cardiology; leaves open optimal approach for whole-heart simulations.
In computational models of swine hearts, ventricular fibrillation signatures are primarily driven by anatomy and structural parameters rather than regional restitution properties, which has implications for the choice of electrophysiological models in large-scale in silico studies.
Ramírez et al. (2020) studied Cardiac arrhythmias. Detailed biophysical electrophysiological modeling vs. Simplified phenomenological modeling was evaluated on Electrical behaviors during steady pacing and sustained ventricular fibrillation. Ventricular fibrillation signatures in computational swine heart models were mainly controlled by anatomy and structural parameters rather than by regional restitution properties.
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