Key result
An anatomically detailed rabbit ventricular model revealed that fine-scale structures like trabeculations and vessels significantly alter excitation and polarization compared to simplified models.
Histoanatomically detailed computational models reveal important microscale differences in cardiac electrophysiology and arrhythmia induction compared to simplified models.
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Requires detailed anatomical features in ventricular models for accurate simulations; leaves open human translation and clinical impact.
Bishop et al. (2009) studied Cardiac electrophysiology modeling. Anatomically detailed MRI-derived rabbit ventricular model vs. Simplified model excluding finer anatomical features was evaluated on Simulations of electrophysiological function (activation, polarization, excitation wavefronts). An anatomically detailed rabbit ventricular model revealed that fine-scale structures like trabeculations and vessels significantly alter excitation and polarization compared to simplified models.
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