Why the study?
Existing common-pool rabbit atrial cardiomyocyte models lack spatially distributed calcium handling, which is important given the less well-developed atrial T-tubular system.
This novel spatial computational model of the rabbit atrial cardiomyocyte successfully reproduces subcellular calcium diffusion patterns, providing a tool to study calcium-handling abnormalities in conditions like atrial fibrillation.
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Novel spatial rabbit atrial model reproduces centripetal Ca waves; hypothesis-generating for AF mechanisms, translation untested.
Vagos et al. (2020) studied this question.
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