Key result
A novel compartmentalized mathematical model of mouse right atrial myocytes demonstrated that T-type Ca2+ current markedly prolongs the later stage of atrial action potential repolarization.
Why the study?
Comprehensive mathematical models describing the complex behavior of the action potential and [Ca 2+ ] i transients in mouse atrial myocytes were lacking.
A novel compartmentalized mathematical model of mouse right atrial myocytes was developed to study complex electrical properties, atrial physiology, and arrhythmogenesis.
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Advances mouse atrial modeling of repolarization; leaves open relevance to human atrial arrhythmias.
Asfaw et al. (2020) studied Mouse atrial myocytes (mathematical model). Compartmentalized mathematical model vs. Ventricular myocytes was evaluated on Action potential and [Ca 2+ ] i transients. A novel compartmentalized mathematical model of mouse right atrial myocytes demonstrated that T-type Ca2+ current markedly prolongs the later stage of atrial action potential repolarization.
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