Why the study?
Although computational models have been developed to investigate mechanisms of atrial fibrillation in several species, no such model existed for adult rat atrial cells.
The development of the first computational model of rat atrial cell action potentials provides a new tool for investigating the pathological mechanisms of atrial fibrillation.
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May aid preclinical AF research in rats; leaves open human translation and clinical relevance.
Zhao et al. (2019) studied this question.
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