Key result
Simulated tachycardia-induced remodeling triggers calcium silencing in 100% of rabbit atrial myocytes via reduced ICaL.
Why the study?
The individual effects and relative importance of cellular remodeling mechanisms leading to calcium silencing in atrial myocytes during atrial fibrillation remain largely unknown.
Absolute Event Rate: 100% vs 0%
Computational modeling demonstrates that decreased ICaL is the predominant driver of calcium silencing in tachycardia-induced remodeling of atrial myocytes.
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Reduced L-type calcium current may drive calcium silencing in modeled atrial remodeling; leaves open translation to human AF mechanisms.
Vagos et al. (2021) studied Atrial Fibrillation / Tachycardia-induced remodeling (n=16). Simulated tachycardia-induced remodeling vs. Baseline computational models was evaluated on Incidence of calcium silencing. Simulated tachycardia-induced remodeling resulted in calcium silencing in 100% of rabbit atrial myocyte models, with reduced L-type calcium current (ICaL) identified as the primary driver.
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