Why the study?
Does sustained high atrial rates alter subcellular Ca2+ signaling in atrial myocytes?
Does sustained high atrial rates alter subcellular Ca2+ signaling in atrial myocytes?
Sustained high atrial rates induce an adaptive silencing of subcellular Ca2+ signaling rather than arrhythmogenic instability.
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High atrial rates may adaptively silence Ca2+ signaling without instability in animal models; leaves open additional triggers for AF arrhythmogenesis.
Greiser et al. (2014) studied this question.
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