Key result
Mathematical modeling of right ventricular apex pacing accurately simulated electromechanics, showing a linear relation between depolarization time and systolic strain (slope -3.80 s-1).
Why the study?
Does a mathematical model of cardiac electromechanics accurately simulate the effects of right ventricular apex pacing compared to experimental dog models?
Population
Mathematical model of cardiac electromechanics and experimental dog model (n=3)
Comparison
Right ventricular apex (RVA) pacing vs Natural sinus rhythm (normal heartbeat)
Design
Preclinical
Authors
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Supports electromechanical modeling of RV pacing in research; leaves open clinical translation pending human validation.
Does a mathematical model of cardiac electromechanics accurately simulate the effects of right ventricular apex pacing compared to experimental dog models?
A relatively simple mathematical model of cardiac electromechanics can accurately simulate the complex events observed during ventricular pacing, showing good agreement with experimental dog models.
Kerckhoffs et al. (2005) studied Ventricular pacing (n=3). Mathematical model of cardiac electromechanics vs. In vivo dog experiments was evaluated on Relation between epicardial depolarization time and systolic midwall circumferential strain. Mathematical modeling of right ventricular apex pacing accurately simulated electromechanics, showing a linear relation between depolarization time and systolic strain (slope -3.80 s-1).
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