Key result
Ventricular pacing for 6 months caused significant asymmetrical hypertrophy in dogs, with the late-activated septum thickening by 23±12%, but did not affect global LV pump function.
Why the study?
Does asynchronous electrical activation induced by ventricular pacing cause asymmetrical hypertrophy and affect left ventricular pump function in adult dogs?
Population
Adult dogs
Comparison
Ventricular pacing for 6 months vs Sham operation
Design
Preclinical, Observer blinded for histological measurements; echocardiographer…
Follow-up
6 months
Authors
Loading...
No change to clinical pacing practice; leaves open whether local load regulates regional LV mass in humans.
Does asynchronous electrical activation induced by ventricular pacing cause asymmetrical hypertrophy and affect left ventricular pump function in adult dogs?
Long-term asynchronous electrical activation from ventricular pacing induces asymmetrical hypertrophy and LV dilatation, demonstrating that local cardiac load regulates local cardiac mass.
Oosterhout et al. (1998) studied this question. Ventricular pacing for 6 months caused significant asymmetrical hypertrophy in dogs, with the late-activated septum thickening by 23±12%, but did not affect global LV pump function.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: