Why the study?
Does ventricular pacing induce local functional and structural changes in the myocardium?
Population
Experimental models and patients with left bundle branch block or hypertrophic obstructive cardiomyopathy
Comparison
Ventricular pacing vs Sinus rhythm
Design
Review
Follow-up
up to 3 months (in dogs)
Authors
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Pacing-induced regional remodeling may underlie HOCM benefits; leaves open human confirmation.
Does ventricular pacing induce local functional and structural changes in the myocardium?
Ventricular pacing induces regional differences in mechanical load that lead to local structural adaptations, which may explain the progressive clinical improvements seen in HOCM patients treated with pacing.
Prinzen et al. (1996) studied this question.
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