Key result
Low-dose prasugrel achieves P2Y12 inhibition in ~96% of clopidogrel-resistant cerebral aneurysm patients without complications.
Why the study?
Does a 20 mg loading dose of prasugrel improve P2Y12 resistance unit (PRU) inhibition in patients with cerebral aneurysms and clopidogrel resistance undergoing stent-assisted coiling?
Observational (n=24)
No
Does a 20 mg loading dose of prasugrel improve P2Y12 resistance unit (PRU) inhibition in patients with cerebral aneurysms and clopidogrel resistance undergoing stent-assisted coiling?
A 20 mg loading dose of prasugrel effectively overcomes clopidogrel resistance in patients undergoing stent-assisted coiling for cerebral aneurysms, achieving adequate platelet inhibition without early hemorrhagic complications.
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May support prasugrel in clopidogrel-resistant aneurysm coiling; hypothesis-generating pending randomized confirmation.
Lee et al. (2018) conducted an observational in Cerebral Aneurysms with Clopidogrel Resistance (n=24). Prasugrel was evaluated on Responder status (PRU inhibition >20%). Low-dose prasugrel achieved effective P2Y12 resistance unit inhibition in 95.8% of clopidogrel-resistant patients undergoing treatment for cerebral aneurysms, with no hemorrhagic or thromboembolic complications.
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