What question did this study set out to answer?

Plasma S100A8/A9 Correlates With Blood Neutrophil Counts, Traditional Risk Factors, and Cardiovascular Disease in Middle-Aged Healthy Individuals

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial finds links between S100A8/A9 levels and cardiovascular risk in healthy individuals, suggesting its utility as a biomarker.

This study investigates the correlation between S100A8/A9 levels and cardiovascular risk factors in healthy middle-aged individuals.
Analyzed S100A8, A9, and A8/A9 levels in 664 individuals aged 63-68 from the Malmö Diet and Cancer cohort
Measured correlations with neutrophil counts, CV risk factors, and carotid artery disease over a median follow-up of 16.2 years
Examined incidence of CV events and death in relation to S100 proteins and neutrophils.
S100A8/A9 positively correlates with neutrophil counts and traditional CV risk factors.
Higher S100A8/A9 levels are linked to increased risk of coronary events (HR 1.28 [1.03-1.59]) and CV death (HR 1.34 [1.06-1.71]).
Associations were notably stronger in women, independent of other risk factors.

Cotoi et al. (2013) studied this question.

View Full Paper

Ask AI

Bookmark

Randomized trial finds links between S100A8/A9 levels and cardiovascular risk in healthy individuals, suggesting its utility as a biomarker.