Key result
Transient aortic occlusion significantly shortened monophasic action potential duration at 90% repolarization (325 to 311 ms, P<0.0001) and Q-T interval (396 to 379 ms, P<0.001).
Why the study?
Do abrupt changes in ventricular loading induced by transient aortic occlusion alter ventricular repolarization in patients undergoing coronary artery surgery?
Population
16 patients undergoing routine coronary artery surgery
Comparison
Transient aortic occlusion to induce acute… vs Preocclusion and postocclusion states
Design
Other
Authors
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May contribute to perioperative arrhythmias via load-dependent repolarization; leaves open causal mechanisms in cardiac surgery.
Do abrupt changes in ventricular loading induced by transient aortic occlusion alter ventricular repolarization in patients undergoing coronary artery surgery?
p-value: p=<0.0001
Abrupt changes in ventricular loading significantly alter the timing of ventricular repolarization, which may contribute to the initiation of arrhythmias.
Taggart et al. (1992) studied Patients undergoing routine coronary artery surgery (n=16). Transient aortic occlusion vs. Preocclusion (baseline) was evaluated on Monophasic action potential duration at 90% repolarization (p=<0.0001). Transient aortic occlusion significantly shortened monophasic action potential duration at 90% repolarization (325 to 311 ms, P<0.0001) and Q-T interval (396 to 379 ms, P<0.001).
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