Key result
Altering the atrioventricular interval to decrease right atrial pressure did not change atrial refractoriness or the frequency of atrial fibrillation induction.
Why the study?
Does varying the AV interval alter atrial refractoriness or the frequency of atrial fibrillation induction in patients without structural heart disease?
Does varying the AV interval alter atrial refractoriness or the frequency of atrial fibrillation induction in patients without structural heart disease?
Alterations in atrial pressure induced by varying the AV interval do not change atrial refractoriness or the frequency of atrial fibrillation induction in patients without structural heart disease, suggesting contraction-excitation feedback may not be a primary mechanism for atrial arrhythmias in this population.
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No support for AV interval changes to influence atrial arrhythmias without structural heart disease; leaves open contraction-excitation feedback in other populations.
Calkins et al. (1992) studied Without structural heart disease (n=27). Varying atrioventricular (AV) intervals during pacing vs. Intra-patient comparison across different AV intervals was evaluated on Atrial effective (ERP) and absolute refractory period (ARP), and frequency of induction of atrial fibrillation. Altering the atrioventricular interval to decrease right atrial pressure did not change atrial refractoriness or the frequency of atrial fibrillation induction.
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