Key result
4-aminopyridine abolished cardiac memory (T wave changes persisting after ventricular pacing) in a canine model, whereas lidocaine did not alter it.
Why the study?
Does 4-aminopyridine or lidocaine alter T wave changes (cardiac memory) induced by ventricular pacing in an open-chest anesthetized dog model?
Population
Open-chest anesthetized dogs
Comparison
4-aminopyridine or lidocaine administered during… vs Control group subjected to the same pacing…
Design
Preclinical
Authors
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Does not support clinical use; leaves open Ito channel role in human cardiac memory.
Does 4-aminopyridine or lidocaine alter T wave changes (cardiac memory) induced by ventricular pacing in an open-chest anesthetized dog model?
Cardiac memory induced by ventricular pacing in dogs is abolished by the transient outward current blocker 4-aminopyridine, suggesting a mechanism related to specific K+ channels.
Balzo et al. (1992) studied Cardiac memory (T wave changes after ventricular pacing). 4-aminopyridine and lidocaine vs. Control (no drug) was evaluated on Changes in T wave amplitude and morphology. 4-aminopyridine abolished cardiac memory (T wave changes persisting after ventricular pacing) in a canine model, whereas lidocaine did not alter it.
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