Key result
Serum CRP shows no independent association with incident ischaemic heart disease after risk-factor adjustment.
Why the study?
The association between serum C-reactive protein and incident ischaemic heart disease is uncertain and may be confounded by various risk factors.
Population
1395 men from the Caerphilly Prospective Heart Disease Study with plasma specimens collected during 1979-83
Comparison
Serum C-reactive protein levels and their association with mortality and cardiovascular risk factors
Design
Prospective cohort study
Follow-up
5-yearly follow-up examinations
Authors
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Adjustment for risk factors nullifies CRP-IHD link; leaves open causality versus confounding and should not change clinical practice.
Cohort (n=1,395)
p-value: p=<0.005
C-reactive protein does not appear to play a direct, independent role in the development of ischaemic heart disease after adjusting for established cardiovascular risk factors like fibrinogen.
Michael A. Mendall (2000) conducted a cohort in ischaemic heart disease (n=1,395). Serum C-reactive protein was evaluated on Incident ischaemic heart disease (p=<0.005). Serum C-reactive protein was positively associated with incident ischaemic heart disease (P<0.005), but this became non-significant after adjustment for non-circulating risk factors.