What question did this study set out to answer?

To develop a computational statistical method that identifies eukaryotic genes regulated cooperatively by transcription factors through the detection of significant DNA binding site clusters.

October 1, 1999Bioinformatics

Genes regulated cooperatively by one or more transcription factors and their identification in whole eukaryotic genomes.

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Authors

AWAndreas WagnerSIB Swiss Institute of Bioinformatics

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Implication

Computational study demonstrates statistical identification of cooperative transcription factor binding clusters in yeast genomes, highlighting a predictive framework to direct experimental gene...

Key Points

To develop a computational statistical method that identifies eukaryotic genes regulated cooperatively by transcription factors through the detection of significant DNA binding site clusters.
Designed a statistical algorithm to detect non-random, tightly linked clusters of transcription factor binding sites representing homotypic (single factor) or heterotypic (multiple factors) cooperativity.
Applied the computational framework across the whole genome of Saccharomyces cerevisiae using two transcription factors associated with mating control and the cell cycle.
Successfully identified statistically significant clusters of transcription factor binding sites across whole eukaryotic genome sequences.
Demonstrated biologically meaningful gene target predictions in yeast, offering a cost-effective computational strategy to guide subsequent wet-lab experiments and annotate uncharacterized open reading frames.

Cite This Study

Andreas Wagner (1999) studied this question.

synapsesocial.com/papers/6a0edba67046b28dbef9a92b https://doi.org/10.1093/bioinformatics/15.10.776

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Implication

Computational study demonstrates statistical identification of cooperative transcription factor binding clusters in yeast genomes, highlighting a predictive framework to direct experimental gene...

Genes regulated cooperatively by one or more transcription factors and their identification in whole eukaryotic genomes.

Discussion

Member takes

Implication

Key Points

Cite This Study

Genes regulated cooperatively by one or more transcription factors and their identification in whole eukaryotic genomes.

Discussion

Member takes

Implication

Key Points

Cite This Study

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