What question did this study set out to answer?

To determine whether positive Darwinian selection drove the emergence of novel anti-pathogen functions following ribonuclease gene duplication in primates.

March 31, 1998Proceedings of the National Academy of SciencesOpen Access

Positive Darwinian selection after gene duplication in primate ribonuclease genes

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Authors

JZJianzhi ZhangHebei Medical University HRHelene F. RosenbergNational Institutes of Health MNMasatoshi NeiRutgers, The State University of New Jersey

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Implication

Phylogenetic sequence analysis demonstrates positive Darwinian selection in primate ribonuclease genes, indicating adaptive functional divergence following gene duplication.

Key Points

To determine whether positive Darwinian selection drove the emergence of novel anti-pathogen functions following ribonuclease gene duplication in primates.
Reconstructed ancestral nucleotide sequences for primate ribonuclease genes, focusing on eosinophil cationic protein (ECP) and eosinophil-derived neurotoxin (EDN).
Calculated and compared the rates of nonsynonymous and synonymous nucleotide substitutions in the duplicated ECP lineage originating approximately 31 million years ago.
The rate of nonsynonymous nucleotide substitution significantly exceeded that of synonymous substitution during the early evolutionary stage of the ECP gene.
A substantial accumulation of arginine residues occurred rapidly following gene duplication, conferring the distinctive anti-pathogen activity seen in ECP but absent in EDN.

Cite This Study

Zhang et al. (1998) studied this question.

synapsesocial.com/papers/6a0edba67046b28dbef9a92f https://doi.org/10.1073/pnas.95.7.3708

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Implication

Phylogenetic sequence analysis demonstrates positive Darwinian selection in primate ribonuclease genes, indicating adaptive functional divergence following gene duplication.

Positive Darwinian selection after gene duplication in primate ribonuclease genes

Discussion

Member takes

Implication

Key Points

Cite This Study

Positive Darwinian selection after gene duplication in primate ribonuclease genes

Discussion

Member takes

Implication

Key Points

Cite This Study

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