Key result
Thiazide and thiazide-like diuretics differ in mechanisms, organ protection, and evidence bases for treating hypertension.
Why the study?
Most patients with arterial hypertension require combination therapy, but thiazide and thiazide-like diuretics differ in their mechanisms of action, pleiotropic effects, organ-protective properties, prognosis effects, and evidence base.
Thiazide and thiazide-like diuretics have distinct pharmacological profiles, organ-protective properties, and evidence bases that should guide their selection in combination therapy for arterial hypertension.
Differences may guide thiazide selection in hypertension combinations; leaves open head-to-head outcome trials.
Most patients with arterial hypertension (AH) require a combination treatment to achieve the goal blood pressure. According to Russian and international clinical guidelines on the treatment of AH patients, various antihypertensive drugs may be combined; however, not all combinations have similar profiles of safety and clinical efficacy. In this respect, special attention is given to combinations of renin-angiotensin-aldosterone system inhibitors and thiazide (hydrochlorothiazide) or thiazide-like (chlortalidone, indapamide) diuretics. Diuretics also differ in their mechanisms of action, presence of pleiotropic effects and organ-protective properties, effects on the prognosis, and in the evidence base. This review discusses the place of thiazide and thiazide-like diuretics in the treatment of patients with AH and provides an evaluation of major differences in pharmacological and clinical effects of drugs of the diuretic class.
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Остроумова et al. (2022) conducted a review in arterial hypertension. Thiazide and thiazide-like diuretics was evaluated. Thiazide and thiazide-like diuretics differ in their mechanisms of action, pleiotropic effects, organ-protective properties, and evidence base for the treatment of arterial hypertension.
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