February 1, 1998Stroke
Relationship Between ApoE, MRI Findings, and Cognitive Function in the Cardiovascular Health Study
Key result
ApoE-4 genotype (OR 1.6; 95% CI 1.1-2.1), high ventricular volume, high white matter grade, and infarctlike lesions were significantly associated with low cognitive scores.
Why the study?
Are ApoE genotype and brain MRI findings associated with low cognitive scores and cognitive decline in older adults?
Population
3,469 black and white participants in the Cardiovascular Health Study (CHS) evaluated in years 5 and 6
Design
Cohort
Follow-up
up to 3 years
Authors
Discussion
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Implication
May identify older adults for closer cognitive monitoring; leaves open whether these markers predict decline or inform interventions.
Key Points
- The aim was to explore the relationship between ApoE, MRI findings, and cognitive function in older adults.
- Evaluated 3469 participants from the Cardiovascular Health Study over 3 years.
- Assessed ApoE genotype, MRI brain examinations, and cognitive scores using the 3MSE.
- Analyzed the impact of age, education, and cardiovascular history on cognitive performance.
- Prevalence of low 3MSE scores was 20.4% among participants with stroke history versus 8.2% without.
- ApoE-4 presence and high ventricular volume significantly increased the odds of low cognitive scores (OR, 1.6).
- Participants with multiple risk factors (low education, older age, incident stroke) showed a greater decline in scores over time.
Study Design
Type
Cohort (n=3,469)
Structured PICO
Are ApoE genotype and brain MRI findings associated with low cognitive scores and cognitive decline in older adults?
P
Population
3,469 black and white participants in the Cardiovascular Health Study (CHS) evaluated in years 5 and 6
O
Outcome
Low (<80) score on the Modified Mini-Mental State Examination (3MSE)surrogate
Main Result
Effect estimate: OR 1.6 (95% CI 1.1 to 2.1)
Vascular changes on MRI, brain atrophy, and ApoE-4 genotype are significantly associated with low cognitive scores and cognitive decline in older adults.
Cite This Study
Kuller et al. (1998) conducted a cohort in Low cognitive scores (n=3,469). ApoE genotype and MRI findings was evaluated on Low (<80) score on the Modified Mini-Mental State Examination (3MSE) (OR 1.6, 95% CI 1.1 to 2.1). ApoE-4 genotype (OR 1.6; 95% CI 1.1-2.1), high ventricular volume, high white matter grade, and infarctlike lesions were significantly associated with low cognitive scores.