Why the study?
Does active antihypertensive drug therapy reduce cognitive, emotional, and physical function and leisure activities in older persons with isolated systolic hypertension?
Population
4736 persons aged 60 years and older with isolated systolic hypertension
Comparison
Active antihypertensive drug therapy vs Matching placebo
Design
RCT, randomized, double-blind
Follow-up
average of 5 years
Key result
Active antihypertensive treatment of isolated systolic hypertension did not cause deterioration in cognition, emotional state, physical function, or leisure activities over 5 years.
Authors
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Supports treating isolated systolic hypertension in older adults; extends long-term safety data for cognition and function.
RCT (n=4,736)
Double-blind
randomized
Yes
Does active antihypertensive drug therapy reduce cognitive, emotional, and physical function and leisure activities in older persons with isolated systolic hypertension?
Medical treatment of isolated systolic hypertension in older adults does not cause deterioration in cognition, emotional state, physical function, or leisure activities.
William B. Applegate (1994) conducted an RCT in isolated systolic hypertension (n=4,736). active antihypertensive drug therapy vs. matching placebo was evaluated on measures of cognitive, emotional, and physical function and leisure activities. Active antihypertensive treatment of isolated systolic hypertension did not cause deterioration in cognition, emotional state, physical function, or leisure activities over 5 years.