Key result
Higher SBP variation and mean heart rate linked to up to ~40% greater cognitive dysfunction risk.
Why the study?
Do high systolic blood pressure visit-to-visit variation and high mean heart rate increase the risk of cognitive dysfunction in patients with high cardiovascular risk?
RCT (n=24,593)
Yes
Do high systolic blood pressure visit-to-visit variation and high mean heart rate increase the risk of cognitive dysfunction in patients with high cardiovascular risk?
Effect estimate: OR 1.32 and OR 1.40 (95% CI 1.10-1.58 and 1.18-1.66)
p-value: p=0.0030 and 0.0008
In patients at high cardiovascular risk, greater visit-to-visit systolic blood pressure variation and higher mean heart rate are independent predictors of cognitive decline and dysfunction.
No takes yet. Share an insight, caveat, or question.
May support monitoring BP variability and heart rate in high-risk patients; leaves open whether targeting them reduces cognitive dysfunction.
Böhm et al. (2015) conducted an RCT in High cardiovascular risk (n=24,593). Visit-to-visit systolic blood pressure variation (SBP-CV) and mean heart rate vs. 1st quintile vs 5th quintile was evaluated on Cognitive dysfunction (fall in mini mental state examination ≤24 points) (OR 1.32 and OR 1.40, 95% CI 1.10-1.58 and 1.18-1.66, p=0.0030 and 0.0008). Higher visit-to-visit systolic blood pressure variation and mean heart rate independently predicted cognitive dysfunction in high cardiovascular risk patients (OR 1.32 and OR 1.40, respectively).
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