Key result
Genetic ablation of PDGFRα+ fibroblasts preserves mouse cardiac function after induced fibrosis and MI.
Why the study?
The role of fibroblasts in maintaining the basal extracellular matrix network and in fibrosis in vivo is poorly understood.
Does genetic ablation of fibroblasts improve cardiac function after injury in adult mice?
Does genetic ablation of fibroblasts improve cardiac function after injury in adult mice?
The adult mouse heart tolerates significant fibroblast loss, which provides a cardioprotective effect and better preserves cardiac function after injury.
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Supports fibroblast targeting in preclinical injury models; leaves open translation to human cardiac disease.
Kuwabara et al. (2022) studied Cardiac fibrosis and myocardial infarction (murine model). Genetic ablation of PDGFRα+ fibroblasts vs. Control mice was evaluated on Cardiac function and extracellular matrix composition. Genetic ablation of PDGFRα+ fibroblasts in adult mice was well-tolerated at baseline and preserved cardiac function following angiotensin II/phenylephrine-induced fibrosis and myocardial infarction.
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