What question did this study set out to answer?

To investigate the time course and underlying physiological mechanisms of blood volume expansion during isotonic exercise training.

April 1, 1980Journal of Applied Physiology

Exercise training-induced hypervolemia: role of plasma albumin, renin, and vasopressin

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To investigate the time course and underlying physiological mechanisms of blood volume expansion during isotonic exercise training.
Evaluated 8 trained men aged 20–22 years (mean VO2max = 57 ml·min⁻¹·kg⁻¹) performing cycle ergometer training at ~160 W (65% VO2max) for 2 hours per day over 8 days.
Periodically measured hemoglobin, hematocrit, plasma volume, osmolality, electrolytes, plasma renin activity, vasopressin, and plasma protein fractions before, during, and after training.
Total blood volume increased by 457 ml (+8.1%, P < 0.05), driven by an increase in plasma volume of 427 ml (+12.1%, P < 0.05), whereas red cell volume remained essentially unchanged (+30 ml, NS).
Plasma hypervolemia was linked to a ninefold acute increase in plasma renin activity and vasopressin during exercise to promote fluid retention, combined with a chronic increase in plasma albumin content that enhanced water-binding capacity.

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Implication

Experimental study reveals that daily high-intensity cycling expands plasma volume in trained young men, indicating hormonal fluid retention and albumin accumulation drive exercise hypervolemia.

Cite This Study

Convertino et al. (1980) studied this question.

synapsesocial.com/papers/6a0ee0d906ecbe833447ea0a https://doi.org/10.1152/jappl.1980.48.4.665

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Implication

Experimental study reveals that daily high-intensity cycling expands plasma volume in trained young men, indicating hormonal fluid retention and albumin accumulation drive exercise hypervolemia.

Exercise training-induced hypervolemia: role of plasma albumin, renin, and vasopressin

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Discussion

Implication

Cite This Study

Exercise training-induced hypervolemia: role of plasma albumin, renin, and vasopressin

Key Points

Discussion

Implication

Cite This Study

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