Key result
Current smoking, total-to-HDL cholesterol ratio, lipoprotein(a), and hs-CRP predicted large-vessel PAD progression, whereas diabetes was the only predictor of small-vessel PAD progression.
Why the study?
Do traditional and novel risk factors differentially predict the progression of large-vessel versus small-vessel peripheral arterial disease?
Cohort (n=403)
Do traditional and novel risk factors differentially predict the progression of large-vessel versus small-vessel peripheral arterial disease?
Risk factors for PAD progression differ by vessel size, with smoking, lipids, and inflammation driving large-vessel disease, while diabetes uniquely drives small-vessel disease progression.
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Differential predictors by vessel size may inform future risk stratification; hypothesis-generating for subtype-specific PAD prevention trials.
Aboyans et al. (2006) conducted a cohort in Peripheral arterial disease (n=403). Traditional and novel risk factors was evaluated on Major progression of large-vessel and small-vessel PAD (defined as -0.30 ABI decrease and -0.27 TBI decrease, respectively). Current smoking, total-to-HDL cholesterol ratio, lipoprotein(a), and hs-CRP predicted large-vessel PAD progression, whereas diabetes was the only predictor of small-vessel PAD progression.
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