October 1, 1992Journal of Internal Medicine
Lipoprotein Lp(a) and peripheral vascular disease
Key result
Lipoprotein(a) concentration is independently associated with peripheral vascular disease, with an odds ratio of 1.35 per 100 mg/L increase (P < 0.01).
Why the study?
Is elevated Lipoprotein(a) concentration associated with peripheral vascular disease?
Population
84 consecutive patients with peripheral vascular disease and 43 healthy controls
Design
Case-control
Authors
Discussion
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Implication
Lp(a) may aid PVD risk stratification; leaves open causality and need for interventional trials.
Study Design
Type
Case-Control (n=127)
Structured PICO
Is elevated Lipoprotein(a) concentration associated with peripheral vascular disease?
P
Population
84 consecutive patients with peripheral vascular disease (of whom 42 had concomitant ischaemic heart disease) and 43 healthy controls
C
Comparator
Healthy controls
O
Outcome
Association of Lipoprotein(a) concentration with peripheral vascular disease
Main Result
Effect estimate: OR 1.35
p-value: p=< 0.01
Lipoprotein(a) concentration is significantly elevated in patients with peripheral vascular disease and serves as an independent risk factor for PVD, regardless of concomitant ischemic heart disease.
Cite This Study
Tyrrell et al. (1992) conducted a case-control in Peripheral vascular disease (n=127). Lipoprotein(a) [Lp(a)] vs. Healthy controls was evaluated on Association of Lp(a) with peripheral vascular disease (OR 1.35, p=< 0.01). Lipoprotein(a) concentration is independently associated with peripheral vascular disease, with an odds ratio of 1.35 per 100 mg/L increase (P < 0.01).