The principles of response surface modelling are briefly described. The computations involved in the canonical analysis of response surface models are given in detail. Three examples of canonical analysis in the context of organic synthesis development are discussed. These examples treat enamine synthesis by a modified titanium tetrachloride procedure, kinetic modelling, and the synthesis of the trimethylsilyl enol ether from methyl vinyl ketone.
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Carlson et al. (2005) studied this question.
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