What question did this study set out to answer?

This research aims to compare the progression of coronary atherosclerosis in patients with unstable angina and those with stable angina.

September 22, 1983New England Journal of Medicine

Unstable Angina and Progression of Coronary Atherosclerosis

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Why the study?

Is unstable angina associated with greater progression of coronary atherosclerosis compared to stable angina?

Population

76 patients who had previously undergone angiography, including 38 hospitalized for an episode of unstable…

Comparison

Unstable angina (exposure) vs Stable angina (matched control)

Design

Case-control

Follow-up

Mean 44 +/- 31 months for unstable angina, 35 +/- 31…

Authors

AMAlain MoiseEuropean Union PTPierre ThérouxRoche (Switzerland)YTYves TaeymansCliniques Universitaires Saint-Luc

Discussion

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Implication

Unstable angina was associated with accelerated lesion progression; this Level 4 evidence leaves open causal inference and practice implications.

Key Points

This research aims to compare the progression of coronary atherosclerosis in patients with unstable angina and those with stable angina.
Included 38 patients with unstable angina and 38 matched patients with stable angina.
Both groups had previous angiography and were evaluated for coronary lesion progression.
Outcomes assessed included the extent of stenosis and the number of patients with multifocal progression.
29 of 38 unstable angina patients exhibited coronary lesion progression compared to 12 of 38 stable angina patients (P < 0.0005).
Progression to 70% or more stenosis occurred in 21 unstable angina patients versus 5 stable angina patients (P < 0.0005).
Multifocal progression was observed in 11 unstable angina patients compared to 2 stable angina patients (P < 0.01).

Structured PICO

Is unstable angina associated with greater progression of coronary atherosclerosis compared to stable angina?

Population

76 patients who had previously undergone angiography, including 38 hospitalized for an episode of unstable angina pectoris and 38 matched patients with stable angina.

Intervention

Unstable angina (exposure)

Comparator

Stable angina (matched control)

Outcome

Progression of atherosclerotic coronary lesions on angiographysurrogate

Unstable angina is strongly associated with angiographic progression in the extent and severity of coronary atherosclerosis compared to stable angina.

Cite This Study

Moise et al. (1983) studied this question.

synapsesocial.com/papers/6a0ee3852eca052da647e370 https://doi.org/10.1056/nejm198309223091201

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Implication

Unstable angina was associated with accelerated lesion progression; this Level 4 evidence leaves open causal inference and practice implications.

Unstable Angina and Progression of Coronary Atherosclerosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Unstable Angina and Progression of Coronary Atherosclerosis

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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