Key result
Induced AF increases atrial fibrillatory rate ~26% in an equine model, demonstrating progressive electrical remodeling.
Why the study?
Horses spontaneously develop AF and could serve as a bona fide model to study the electrical, functional, and structural remodelling caused by chronic AF.
Does tachypacing-induced chronic atrial fibrillation cause electrical, functional, and structural remodeling in an equine model?
Does tachypacing-induced chronic atrial fibrillation cause electrical, functional, and structural remodeling in an equine model?
Absolute Event Rate: 376% vs 299%
p-value: p=<0.01
An equine model of tachypacing-induced atrial fibrillation successfully demonstrates electrical, functional, and structural remodeling similar to human AF, providing a valuable large animal model for future research.
No takes yet. Share an insight, caveat, or question.
No immediate clinical implications; supports equine tachypacing model for future AF remodeling research.
Hesselkilde et al. (2019) studied Atrial Fibrillation (n=9). Tachypacing-induced atrial fibrillation vs. Time-matched sham-operated control was evaluated on Atrial fibrillatory rate (AFR) at day 55 compared to day 1 (p=<0.01). In an equine model of induced atrial fibrillation, atrial fibrillatory rate significantly increased from 299 fpm at day 1 to 376 fpm at day 55 (p<0.01), demonstrating progressive electrical remodeling.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: