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November 12, 2025Journal of Biomedical ScienceOpen Access

Technological advancements in antibody-based therapeutics for treatment of diseases

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Authors

RLRuei‐Min LuHCHsiao-Ling ChiangJYJoyce Pei‐Yi Yuan

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Overview

Review highlights rapid technological innovations in antibody-based therapeutics across clinical disease domains, suggesting expanding opportunities for precision medicine.

Key Points

  • To review the technological evolution, structural modalities, discovery platforms, and market dynamics of therapeutic antibodies across major clinical domains.
  • Synthesized platform developments spanning hybridoma technology, phage display, transgenic mice, and single B cell isolation from 1975 through 2025.
  • Evaluated advanced therapeutic formats including antibody-drug conjugates, bispecific antibodies, CAR-T cell engineering, and artificial intelligence-guided optimization.
  • Documented 144 FDA-approved antibody drugs on the market and 1,516 clinical candidates actively in global development as of August 2025.
  • Identified worldwide antibody therapeutic sales exceeding USD 267 billion in 2024, underpinned by diversification into bispecifics and antibody-drug conjugates.
  • Demonstrated that integrating artificial intelligence, next-generation sequencing, and mRNA-lipid nanoparticles enhances target affinity, in vivo delivery, and manufacturing efficiency.

Cite This Study

Lu et al. (2025) studied this question.

synapsesocial.com/papers/6a0ee7fa950456576347dddahttps://doi.org/10.1186/s12929-025-01190-2
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