Key result
Elevated E/(e′s′) ratio linked to ~7-point higher SYNTAX scores in NSTE-ACS.
Why the study?
The study was conducted to evaluate whether the tissue Doppler-derived E/(e's') ratio is associated with coronary atherosclerosis severity, measured by the SYNTAX score, in patients with NSTE-ACS.
Does the tissue Doppler-derived E/(e′s′) ratio associate with coronary atherosclerosis severity measured by the SYNTAX score in patients with NSTE-ACS?
Observational (n=252)
No
Does the tissue Doppler-derived E/(e′s′) ratio associate with coronary atherosclerosis severity measured by the SYNTAX score in patients with NSTE-ACS?
Effect estimate: B 5.609 (95% CI 2.324-8.894)
Absolute Event Rate: 28% vs 21%
p-value: p=0.001
An E/(e′s′) ratio ≥ 1.63 is independently associated with a higher SYNTAX score and worse clinical profiles in patients with NSTE-ACS, suggesting its utility as a non-invasive marker of coronary atherosclerosis severity.
May support noninvasive estimation of atherosclerosis burden in NSTE-ACS; hypothesis-generating and requires prospective validation before clinical use.
Background The prognosis of patients hospitalized with non-ST elevation-acute coronary syndrome (NSTE-ACS) is typically determined by the existence and severity of myocardial necrosis and left ventricular (LV) remodeling. Aim The present study was to assess the association between the E/(e′s′) ratio and the coronary atherosclerosis severity, measured by the SYNTAX score, in patients with NSTE-ACS. Methods Utilizing a descriptive correlational research design, this study was prospectively conducted on 252 patients with NSTE-ACS, undergoing an echocardiography to determine the left ventricular ejection fraction (LVEF), the left atrial (LA) volume, the pulsed-wave (PW) Doppler-derived transmitral early (E) and late (A) diastolic velocities, and the tissue Doppler (TD)-derived mitral annular early diastolic (e′) and peak systolic (s′) velocities. After that, a coronary angiography (CAG) was performed, and the SYNTAX score was calculated. Results The patients were divided into two groups, viz., those with the E/(e′s′) ratio < 1.63 and the cases with the ratio ≥ 1.63. The results revealed that the patients with a high ratio were older, had a higher prevalence of females, a SYNTAX score ≥ 22, and a lower glomerular filtration rate than those with a low ratio ( p -value < 0.001). Besides, these patients had larger indexed LA volume and lower LVEF than others ( p -value: 0.028 and 0.023, respectively). Furthermore, the multiple linear regression outcomes established a positive independent association between the E/(e′s′) ratio ≥ 1.63 (B = 5.609, 95% CI 2.324–8.894, p -value = 0.001) and the SYNTAX score. Conclusion The study results demonstrated that the patients hospitalized with NSTE-ACS and the E/(e′s′) ratio ≥ 1.63 had worse demographic, echocardiographic, and laboratory profiles and a higher prevalence of a SYNTAX score ≥ 22 than those with a lower ratio.
No takes yet. Share an insight, caveat, or question.
Nabati et al. (2023) conducted an observational in Non-ST elevation-acute coronary syndrome (NSTE-ACS) (n=252). E/(e′s′) ratio ≥ 1.63 vs. E/(e′s′) ratio < 1.63 was evaluated on SYNTAX score (B 5.609, 95% CI 2.324-8.894, p=0.001). An E/(e′s′) ratio ≥ 1.63 was independently associated with a higher SYNTAX score (B 5.609) compared to a ratio < 1.63 in patients hospitalized with non-ST elevation-acute coronary syndrome.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: