Key result
Bacteriophage T4 RNA ligase 2 (Rnl2) catalyzes intramolecular and intermolecular RNA strand joining through ligase-adenylate and RNA-adenylate intermediates, exemplifying a distinct ligase family.
Population
Bacteriophage T4 RNA ligase 2 (gp24.1) expressed in E. coli BL21(DE3)
Comparison
Biochemical characterization and mutational… vs Wild-type Rnl2
Design
Preclinical
Authors
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No immediate clinical implications; extends RNA ligase families across phylogenetic domains.
Identification of T4 Rnl2 reveals a distinct family of RNA ligases conserved across phylogenetic domains, expanding the understanding of RNA repair mechanisms.
Ho et al. (2002) studied this question. Bacteriophage T4 RNA ligase 2 (Rnl2) was evaluated. Bacteriophage T4 RNA ligase 2 (Rnl2) catalyzes intramolecular and intermolecular RNA strand joining through ligase-adenylate and RNA-adenylate intermediates, exemplifying a distinct ligase family.
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