Key result
BMI ≥ 27 linked to ~183% higher nonrheumatic aortic valve mortality vs BMI 21-22.9.
Why the study?
The study was conducted to examine the impact of overweight and obesity on mortality from nonrheumatic aortic valve disease.
Does higher body mass index increase mortality from nonrheumatic aortic valve disease in Japanese adults?
Cohort (n=98,378)
Yes
Does higher body mass index increase mortality from nonrheumatic aortic valve disease in Japanese adults?
Effect estimate: HR 2.83 (95% CI 1.20-6.65)
Absolute Event Rate: 0.75% vs 0.27%
p-value: p=0.006
Overweight and obesity (BMI ≥ 27 kg/m²) are independently associated with an approximately threefold increased risk of mortality from nonrheumatic aortic valve disease in Japanese adults.
AIM: We aimed to examine the impact of overweight and obesity on mortality from nonrheumatic aortic valve disease. METHODS: In the Japan Collaborative Cohort Study, we analyzed data of 98,378 participants aged 40-79 years, with no history of coronary heart disease, stroke, or cancer at baseline (1988-1990) and who completed a lifestyle questionnaire including height and body weight; they were followed for mortality until the end of 2009. The Cox proportional hazards model was used to calculate the multivariable hazard ratios (HRs) with 95% confidence intervals (CIs) of nonrheumatic aortic valve disease mortality according to body mass index (BMI) after adjusting for potential confounding factors. RESULTS: . Similar associations were observed between men and women (p for interaction=0.56). Excluding those who died during the first ten years of follow-up or a competing risk analysis with other causes of death as competing risk events did not change the association materially. CONCLUSIONS: Overweight and obesity may be independent risk factors for nonrheumatic aortic valve disease mortality in Asian populations.
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Teramoto et al. (2022) conducted a cohort in Nonrheumatic aortic valve disease (n=98,378). Body mass index ≥ 27 kg/m2 vs. Body mass index 21-22.9 kg/m2 was evaluated on Mortality from nonrheumatic aortic valve disease (HR 2.83, 95% CI 1.20-6.65, p=0.006). A body mass index of ≥ 27 kg/m2 was associated with a significantly increased risk of mortality from nonrheumatic aortic valve disease compared to a BMI of 21-22.9 kg/m2 (HR 2.83).
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