Histologic classification of Hodgkin's disease

Ninety-seven cases of Hodgkin's disease with 5 to 15 year follow-up were classified according to the recommendation of the Symposium on the Obstacles to the Control of Hodgkin's Disease, presented in New York in 1965, into four histologic groups: lymphocytic predominance, nodular sclerosis, mixed cellularity and lymphocytic depletion. A definite correlation was found between survival and the different groups, the first two groups having a markedly better prognosis than the last two. The nodular sclerosis type differed in many respects from the other types. In this group were more young patients and more females than in the other groups. Also, mediastinal and osseous involvement was more common. These facts argue for the assumption that the nodular sclerosis type is not merely evidence of the good reaction of the organism but that this type is a distinct form of Hodgkin's Disease from the onset, a clinicopathologic entity.