Key result
Homozygosity for the rare allele of the ecNOS gene was associated with significantly higher plasma NOx levels compared to homozygosity for the common allele (64.9 vs 30.2 μmol/L; P=0.000242).
Population
428 members of 108 nuclear families
Design
Cross-sectional
Authors
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ecNOS genotype was associated with basal NOx; leaves open relevance to atherogenesis pending longitudinal validation.
Observational (n=428)
Absolute Event Rate: 64.9% vs 30.2%
p-value: p=0.000242
The ecNOS locus has a substantial effect on the variance of basal plasma NO production, which may be relevant to atherogenesis and NO-related disorders.
Wang et al. (1997) reported an observational. ecNOS gene rare allele vs. ecNOS gene common allele was evaluated on plasma NOx levels (p=0.000242). Homozygosity for the rare allele of the ecNOS gene was associated with significantly higher plasma NOx levels compared to homozygosity for the common allele (64.9 vs 30.2 μmol/L; P=0.000242).
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