Key result
L-arginine administration in hypercholesterolemic rabbits reduced preexisting intimal lesion surface area to 5.4% at 23 weeks, compared to a progression to 56.5% in vehicle-treated controls.
Why the study?
Does L-arginine improve NO-dependent vasodilation and reduce lesion surface area in hypercholesterolemic rabbits with preexisting intimal lesions?
Population
New Zealand White rabbits fed 0.5% cholesterol chow for 10 weeks to induce preexisting intimal lesions
Comparison
L-arginine for 13 weeks while continuing… vs Vehicle for 13 weeks while continuing…
Design
Preclinical
Follow-up
13 weeks of treatment
Authors
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Animal data suggest lesion regression; leaves open translation to human hypercholesterolemia.
Does L-arginine improve NO-dependent vasodilation and reduce lesion surface area in hypercholesterolemic rabbits with preexisting intimal lesions?
Absolute Event Rate: 5.4% vs 56.5%
L-arginine administration restores NO activity and induces regression of preexisting intimal lesions in a hypercholesterolemic rabbit model.
Candipan et al. (1996) studied Hypercholesterolemia. L-arginine vs. Vehicle was evaluated on Lesion surface area at 23 weeks. L-arginine administration in hypercholesterolemic rabbits reduced preexisting intimal lesion surface area to 5.4% at 23 weeks, compared to a progression to 56.5% in vehicle-treated controls.
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