What question did this study set out to answer?

To investigate whether amyloid-β drives longitudinal entorhinal cortex atrophy independently or requires the presence of phosphorylated tau in nondemented individuals.

June 7, 2011Annals of Neurology

Amyloid‐β associated volume loss occurs only in the presence of phospho‐tau

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To investigate whether amyloid-β drives longitudinal entorhinal cortex atrophy independently or requires the presence of phosphorylated tau in nondemented individuals.
Assessed 286 nondemented individuals (N=286; 107 cognitively normal older adults and 179 memory-impaired individuals) who underwent serial MRI scans and baseline lumbar puncture.
Quantified baseline cerebrospinal fluid levels of CSF Aβ(1-42) and CSF p-tau(181p).
Modeled longitudinal entorhinal cortex atrophy rates relative to biomarker levels using linear mixed-effects models.
Accelerated entorhinal cortex volume loss significantly correlated with lower CSF Aβ(1-42) only in participants exhibiting elevated CSF p-tau(181p).
Amyloid-β pathology in the absence of elevated phospho-tau was not associated with elevated rates of entorhinal cortex neurodegeneration.

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Implication

Longitudinal study reveals that amyloid-beta drives entorhinal cortex atrophy only when phospho-tau is elevated in nondemented adults, suggesting both proteins are required for neurodegeneration.

Cite This Study

Desikan et al. (2011) studied this question.

synapsesocial.com/papers/6a0ef589a14f152feafa1351 https://doi.org/10.1002/ana.22509

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Implication

Longitudinal study reveals that amyloid-beta drives entorhinal cortex atrophy only when phospho-tau is elevated in nondemented adults, suggesting both proteins are required for neurodegeneration.

Amyloid‐β associated volume loss occurs only in the presence of phospho‐tau

Key Points

Discussion

Implication

Cite This Study

Amyloid‐β associated volume loss occurs only in the presence of phospho‐tau

Key Points

Discussion

Implication

Cite This Study

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