Why the study?
The clinical significance and appropriate therapeutic management of atrial high-rate events or subclinical atrial fibrillation detected by implantable devices remain incompletely defined, even after recent randomized trials.
Does anticoagulant therapy improve outcomes in patients with subclinical AF or AHREs identified by cardiac devices?
Does anticoagulant therapy improve outcomes in patients with subclinical AF or AHREs identified by cardiac devices?
Anticoagulation for subclinical AF or AHREs requires individualized assessment of episode burden and CHA2DS2-VASc score due to a lower baseline thromboembolic risk compared to clinical AF.
Answers are grounded in this paper and cite their sources.
May warrant individualized anticoagulation decisions in device-detected subclinical AF; leaves open optimal thresholds pending randomized trials.
Implantable cardiac devices have shown that atrial fibrillation (AF) is more frequent than previously assumed, with subclinical, asymptomatic, self-limiting manifestations called atrial high-rate events (AHREs) or subclinical AF. The clinical significance and correct therapeutic management of these episodes of subclinical AF is less well defined than in the case of clinically manifest AF. Two important randomized studies on the topic have recently been published, NOAH-AFNET 6 and ARTESIA, which, however, have not definitively clarified the topic. In patients with AHRE or subclinical AF, the average thrombo-embolic risk is lower than that in patients with clinically manifest AF and is ∼1%. For this reason, in these patients, the possibility that the benefit of anticoagulant therapy is overshadowed by the risk of bleeding is very high. Therefore, while waiting for new tools that allow a better stratification of low-risk patients, we must rely on individual clinical evaluation and overcome the qualitative dichotomy (AHRE yes vs. AHRE no), preferring instead an approach that is as quantitative as possible and takes into account the number of episodes, their duration, and the patient's CHADSVASC score, before deciding, in each individual case, whether or not to use anticoagulant therapy.
No takes yet. Share an insight, caveat, or question.
F Stazi (2024) conducted a review in Atrial high-rate events (AHREs) or subclinical atrial fibrillation. Anticoagulant therapy was evaluated.
Synapse has enriched 10 related papers. Consider them for comparative context: