What question did this study set out to answer?

This research aims to investigate how insulin activates a specific protein kinase in adipocytes and placental tissues.

Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta.

View Full Paper

Ask AI

Bookmark

Authors

Randomized trial demonstrates insulin's activation of protein kinase in human tissue, indicating insulin's role in cellular signaling.

This research aims to investigate how insulin activates a specific protein kinase in adipocytes and placental tissues.
Direct addition of insulin to detergent extracts of differentiated 3T3-L1 adipocytes and human placental membranes.
Assessment of kinase activation via antibody to the insulin receptor and proinsulin.
Analysis of phosphorylation effects on insulin receptor components and histones.
Insulin activates a tyrosine-specific protein kinase in 3T3-L1 adipocytes and human placenta.
The kinase phosphorylates the 92,000-dalton component of the insulin receptor, histone, and casein, primarily at tyrosine residues.
Insulin does not change the dephosphorylation rate of the receptor or histone under the tested conditions.

Petruzzelli et al. (1982) studied this question.

View Full Paper

Ask AI

Bookmark