What question did this study set out to answer?

To examine the dual role of autophagy in tumor survival and evaluate strategies for repositioning established non-oncology drugs to induce cancer cell death.

March 9, 2017Journal of Hematology & OncologyOpen Access

Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment

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Authors

GYGo J. YoshidaKeio University

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Implication

Review demonstrates that modulating autophagy via drug repositioning triggers cancer cell death, highlighting cost-effective therapeutic alternatives to conventional oncology drug development.

Key Points

To examine the dual role of autophagy in tumor survival and evaluate strategies for repositioning established non-oncology drugs to induce cancer cell death.
Synthesized molecular evidence on autophagy regulation, the PI3K/Akt/mTOR pathway, and endoplasmic reticulum stress in tumor microenvironments.
Reviewed preclinical and clinical evidence on repurposing non-cancer pharmaceuticals, including antimalarial agents and disease-modifying antirheumatic drugs, to target autophagic flux.
Autophagy functions as a context-dependent mechanism that promotes tumor survival under nutrient starvation but induces apoptotic cell death when lysosomal flux is disrupted.
Inhibition of mTOR alone frequently fails to eliminate cancer cells, whereas blocking autophagic degradation triggers endoplasmic reticulum stress and unfolded protein responses.
Drug repositioning provides a viable approach to cancer therapy by utilizing established agents with known safety profiles to bypass high drug-development failure rates.

Cite This Study

Go J. Yoshida (2017) studied this question.

synapsesocial.com/papers/6a0efb6606ecbe833448074d https://doi.org/10.1186/s13045-017-0436-9

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Implication

Review demonstrates that modulating autophagy via drug repositioning triggers cancer cell death, highlighting cost-effective therapeutic alternatives to conventional oncology drug development.

Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

Therapeutic strategies of drug repositioning targeting autophagy to induce cancer cell death: from pathophysiology to treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

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