Key result
Long-term storage of plasma samples at -80°C for 28 months caused a significant 4.83% decrease in measured Lp(a) concentrations (from 21.24 to 20.02 mg/dL, P<.001).
Why the study?
Does long-term plasma sample storage at -80 degrees C reduce measured lipoprotein(a) concentrations?
Observational (n=310)
Does long-term plasma sample storage at -80 degrees C reduce measured lipoprotein(a) concentrations?
Absolute Event Rate: 20.02% vs 21.24%
p-value: p=<.001
Long-term storage of plasma samples at -80°C leads to a significant decrease in measured Lp(a) concentrations, particularly for low-molecular-weight apo(a) isoforms, potentially confounding retrospective analyses.
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Long-term storage at −80°C was associated with lower measured Lp(a); leaves open whether archived samples bias retrospective analyses.
Kronenberg et al. (1996) reported an observational. Long-term plasma sample storage at -80 degrees C vs. 3 months of storage was evaluated on Lp(a) concentration (p=<.001). Long-term storage of plasma samples at -80°C for 28 months caused a significant 4.83% decrease in measured Lp(a) concentrations (from 21.24 to 20.02 mg/dL, P<.001).
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